Starting in fall 2025, Prenatal Screening Ontario (PSO) will implement two new publicly funded, non-invasive prenatal tests: Fetal RhD Screening and Alloimmunized Fetal Blood Group Genotyping (Allo-FBGG). These cell-free DNA-based assays enable early, accurate fetal antigen determination in RhD-negative and alloimmunized pregnancies. This allows for more precise RhIG administration and targeted monitoring for hemolytic disease of the fetus and newborn (HDFN), reducing unnecessary interventions and referrals. Tests can be ordered directly by primary care providers, supporting more efficient, patient-centered prenatal care across Ontario. Objectives:
Explain the clinical significance of the new non-invasive fetal blood group genotyping tests and how implementation will enhance and influence current practice.
Describe when to order fetal blood group genotyping and understand how precision medicine can help guide more targeted and equitable access to pregnancy care.
Identify reliable sources for additional information, guidance, and clinical resources related to the new non-invasive fetal blood group genotyping tests.
SPEAKERS:
Dr. Anjali Oberai, MD, FCFP
Speaker biography:
Credentials: Dr. Anjali Oberai MD, FCFP; Associate Professor NOSM U; Co-Chair Section of Family Medicine NOSM U
Dr. Anjali Oberai earned her undergraduate medical degree from the University of Ottawa in 1993 and completed her family medicine residency at the University of Calgary in 1995. After several years working as a rural locum across Nunavut, Alberta, and Ontario, she settled in Wawa, Ontario, where she has been practicing as a rural generalist since 1998. Her full-scope practice includes clinic work, emergency care, obstetrics, and inpatients. She also has an interest in exercise stress testing and provides this service to her community. Dr. Oberai is currently serving as a Family Medicine Advisor to Prenatal Screening Ontario and the Better Outcomes Registry & Network of Ontario. Dr. Oberai and her husband raised their two incredible children in Wawa, a place she is grateful to call home. Outside of work, she enjoys exploring the outdoors and embracing the joys of rural living.